
Director, Metabolic Disorders, DECISION RESOURCES, INC.
Member of the Healthcare Council
Donny Wong, Ph.D., is the therapeutic area director for metabolic disorders at Decision Resources, Inc., where he has authored over 30 market research reports covering type 2 diabetes, obesity, dyslipidemia, metabolic syndrome, diabetic complications, and other disorders. Dr. Wong’s research, analysis, and commentaries have appeared in numerous media outlets including the Wall Street Journal, Barron’s, Pharmaceutical Executive, Forbes, In Vivo, PharmaVoice, and BBC America. His previous experience includes 12 years of scientific research conducted at Harvard University, the Massachusetts Institute of Technology, Praecis Pharmaceuticals, and the U.S. Department of Agriculture. Dr. Wong attended MIT and Williams College and earned M.Sc. and Ph.D. degrees from Harvard University. (This is me - Update Profile)
Improvements to CV risk factors, but magnitude very low
October 27, 2009
Arena: 2nd weight loss trial shows cardiac benefit | www.reuters.com
Arena presented data on lorcaserin at a series of presentations this week at the 2009 meeting of The Obesity Society in Washington DC. Data from both the BLOOM and BLOSSOM Phase III studies were presented, although BLOOM data had been released for some time already.
Unclear how orlistat's mechanism can lead to liver damage. Likely a non-issue.
August 28, 2009
FDA Investigating Reports of Liver Injury in Patients Using Weight Loss Drug Orlistat | www.webmd.com
Orlistat is designed to act peripherally in the GI tract and studies have demonstrated negligible systemic absorption of orlistat. Patients suffering from liver damage are either hypersensitive to orlistat or have taken too much of the drug. It is likely that these cases of liver injury are unrelated to orlistat, since obesity predisposes patients for liver damage. But overall cases of liver damage are small compared to the total number of patients who have taken the drug over the years.